Glomerulonephritis: Causes, Symptoms, Diagnosis & Treatment

Glomerulonephritis: Causes, Symptoms, Diagnosis & Treatment

December 19, 2025 Dr. Nirbhai Kumar0
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Understanding Glomerulonephritis 

Glomerulonephritis occurs when the glomeruli are damaged or inflamed. These structures filter waste, excess salts, and fluids from the blood to produce urine. Inflammation reduces their filtering ability, leading to waste buildup, fluid retention, and other complications. 

Acute glomerulonephritis usually appears suddenly, often after infections such as streptococcal throat or skin infections. 

Chronic glomerulonephritis develops gradually over months or years and may result from autoimmune diseases, long-standing hypertension, or other causes of sustained kidney injury. 

Causes of Glomerulonephritis 

Glomerulonephritis can be triggered by several factors: 

  • Post-infectious: Following bacterial infections such as streptococcal throat or skin infections 
  • Autoimmune diseases: Lupus, IgA nephropathy, and Goodpasture syndrome 
  • Chronic conditions: Long-standing hypertension and diabetes can worsen glomerular damage and accelerate disease progression 
  • Medications: Certain drugs (e.g., NSAIDs) may worsen kidney injury in susceptible individuals 
  • Genetic factors: Inherited conditions such as Alport syndrome 

Understanding the cause is essential to guide treatment and prevent recurrence. 

Also Read: Top 10 Foods for Kidney Health

Key Symptoms of Acute and Chronic Glomerulonephritis 

Symptoms Acute GN Chronic GN
Hematuria Sudden, visible blood in urine Mild or intermittent
Edema Rapid onset (face, hands, feet, abdomen) Gradual swelling (ankles, around eyes)
Blood Pressure Often elevated Chronically high
Urine Output Sudden decrease Gradual decline
Fatigue Moderate Persistent and worsening
Appetite & Digestion Usually normal Poor appetite, nausea

Diagnosis of Glomerulonephritis 

Accurate diagnosis involves a combination of tests: 

  • Urine tests: Detect blood, protein, or abnormal sediment 
  • Blood tests: Assess kidney function (creatinine, BUN, electrolytes) 
  • Imaging: Ultrasound or CT scan to evaluate kidney size and structure 
  • Kidney biopsy: Confirms the diagnosis and identifies the specific type of glomerulonephritis 

Also Read: 10 Foods that Cause Kidney Stones

Treatment of Glomerulonephritis 

Treatment aims to control inflammation, protect kidney function, and address the underlying cause. 

Treatment Purpose
Medications Corticosteroids or immunosuppressants; antibiotics if infection-related
Blood Pressure Control ACE inhibitors or ARBs to reduce proteinuria
Diuretics Manage fluid overload and edema
Dietary Measures Low-salt, appropriate protein intake
Dialysis For advanced kidney failure
Kidney Transplant In end-stage kidney disease

Acute cases may recover completely, while chronic forms require long-term follow-up. 

  • Prevention & Lifestyle Tips 
  • Control blood pressure and blood sugar 
  • Follow a kidney-friendly diet 
  • Limit salt and processed foods 
  • Stay well hydrated 
  • Avoid smoking and excess alcohol 
  • Exercise regularly 
  • Regular kidney monitoring in high-risk individuals 

Conclusion 

Glomerulonephritis can have a serious impact on kidney health, but early diagnosis and proper treatment can help slow or prevent disease progression. Being aware of the symptoms and seeking timely medical care is essential. For expert evaluation and personalized treatment, consulting a nephrologist in Lucknow at Regency Hospitals can ensure the best care and support for maintaining healthy kidney function.

Also Read: Chronic Kidney Disease: Symptoms, Diagnosis and Treatment Options 

Frequently Asked Questions (FAQs) 

What are the three types of glomerulonephritis?

Acute, chronic, and rapidly progressive glomerulonephritis.

Can glomerulonephritis be cured?

Acute cases may resolve completely with treatment, while chronic forms usually require long-term or lifelong management.

Which immune diseases cause glomerulonephritis?

Autoimmune conditions such as lupus, IgA nephropathy, Goodpasture syndrome, and vasculitis can lead to glomerulonephritis.

Can exercise reverse kidney disease?

Exercise supports overall health and kidney function but cannot reverse established kidney damage.

What damages the kidneys the most?

Uncontrolled high blood pressure, diabetes, chronic inflammation, and recurrent infections are major causes of kidney damage.

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